In-silico model of skin



Since the enforcement of regulation prohibiting the use of animal or animal derived substances for the development and testing of consumer, cosmetic and pharmaceutical ingredients (EU regulation 76/768/EEC), there has been considerable focus on the development, evaluation and integration of alternative approaches (e.g. in silico approaches such as (Q)SARs and expert systems) for skin sensitization hazard and risk assessment. These studies open an interesting window for INTUITIVE as they could be extended to develop the in-silico model of skin to investigate the transduction mechanism in soft-skin at molecular scale. The fellow involved in this project will develop the in-silico models of skin by considering the receptors in soft skin at various depths and role of various soft materials. Here we will incorporate new findings in the synthetic material to be used for making of artificial tactile sensing skin.

Expected Results

Molecular scale mechanism of mechanoreceptors in skin for better design of tactile sensors in artificial skin.


Host institution: University of Glasgow

Enrolments (in Doctoral degree): University of Glasgow


Ravinder Dahiya, Beena Rai

Presentation of ESR4

PhD defense: Tentative period – July 2024

Shashank Mishra

I am Shashank Mishra, and I am from India. I have done an integrated dual degree course (B.Tech. and M.Tech.) in Metallurgical Engineering from IIT-BHU, Varanasi. After my post-graduation, I have worked in Tata Consultancy Services R&I Labs, Pune, India as a researcher. I have experience in modelling and simulation of materials at nanoscale level using techniques like molecular dynamics simulations and coarse-grained simulations. In this project, I would be modelling the skin to investigate the transduction mechanism.

Abstract of PhD goals

This PhD thesis presents the fabrication and modeling of flexible sensors tailored for robotics and prosthetics applications. Furthermore, it introduces an artificial tactile system utilizing these flexible sensors and illustrates its practical application. Additionally, it delves into the development of an in-silico model of the human tactile system, exploring its influence on the creation of the artificial tactile system.


Deliverable 2.4 Report on molecular scale mechanism of mechanoreceptors in skin 
Develop molecular scale model of mechanoreceptors of the skin. Incorporate biomimetic mechanoreceptor models in synthetic material to be used for artificial skin.

Deliverable 2.6 Multi-scale model of synthetic materials mimicking tactile sensing in skin
Validate in-silico model with experimental data. Use the in silico model for design and development of realistic tactile sensing skin

Journal Article
Mishra, S.; Nair, N.M.; Khandelwal, G.; Rai, B.; Georgiev, V.
Capacitive-Triboelectric-Based Hybrid Sensor System for Human-Like Tactile Perception
IEEE Sensors Letters, 2024

Journal Article
Kumaresan, Y.;  Mishra, S.; Ozioko, O.; Chirila, R.; Dahiya, R.
Ultra-High Gauge Factor Strain Sensor with Wide-Range Stretchability
Advanced Intelligent Systems, 2022
DOI: 10.1002/aisy.202200043

Conference Article
Mishra, S.;  Shojaei Baghini, M.; Shakthivel, D.; Rai, B.; Dahiya, R.
Sensitivity Analysis of ZnO NWs Based Soft Capacitive Pressure Sensors Using Finite Element Modeling
IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS), 2022
DOI: 10.1109/FLEPS53764.2022.9781566